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> home > Products > Primary Antibodies > Neuroscience > Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16)
Anti-Tyrosine Hydroxylase Antibody (Monoclonal, TH-16)
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Application 
| WB, IHC-P, IHC-F |
|---|---|
| Primary Accession | P04177 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Tyrosine Hydroxylase, tyrosine hydroxylase (TH) detection. Tested with WB, IHC-P, IHC-F in Human;rat;rabbit. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 25085 |
|---|---|
| Other Names | Tyrosine 3-monooxygenase, 1.14.16.2, Tyrosine 3-hydroxylase, TH, Th |
| Calculated MW | 55966 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, rat, rabbit, By Heat Immunohistochemistry(Frozen Section), 0.5-1 µg/ml, Human, rat, rabbit, - Western blot, 0.25-0.5 µg/ml, Human, rat, rabbit |
| Tissue Specificity | TH: Mainly expressed in the brain and adrenalglands. |
| Protein Name | Tyrosine 3-monooxygenase |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | TH-16 |
| Immunogen | Rat tyrosine hydroxylase(TH). |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. |
| Name | Th |
|---|---|
| Function | Catalyzes the conversion of L-tyrosine to L- dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan but with lower specificity (PubMed:11922614, PubMed:10933781). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P24529}. Nucleus Cell projection, axon {ECO:0000250|UniProtKB:P24529}. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well as at Ser-40 shows a cytosolic distribution (PubMed:21392500). Expressed in dopaminergic axons and axon terminals (By similarity) {ECO:0000250|UniProtKB:P07101, ECO:0000269|PubMed:21392500} |
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Human TH gene contains 13 primary exons and spans approximately 8 kb. TH is in the 11p15.5 region.
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$ 280.00
Cat# ABO10484
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