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Anti-TIMP-4 Antibody

     
  • WB - Anti-TIMP-4 Antibody ABO10561
    Anti-TIMP4 antibody, ABO10561, Western blottingAll lanes: Anti TIMP4 (ABO10561) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 25KDObserved bind size: 25KD
    detail
  • IHC - Anti-TIMP-4 Antibody ABO10561
    Anti-TIMP4 antibody, ABO10561, IHC(P) IHC(P): Rat Kidney Tissue
    detail
  • IHC - Anti-TIMP-4 Antibody ABO10561
    Anti-TIMP4 antibody, ABO10561, IHC(P) IHC(P): Human Mammary Cancer Tissue
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q99727
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Liquid
Description Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 4(TIMP4) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Additional Information
Gene ID 7079
Other Names Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4, TIMP4
Calculated MW 25503 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Secreted.
Tissue Specificity Abundant in heart and present at low levels in many other tissues.
Protein Name Metalloproteinase inhibitor 4
Contents Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4. Carrier free (No BSA) form available in stock. If you want this antibody carrier free please specify Carrier Free" or "No BSA" in your order note. "
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP4(208-224aa YRGHLPLRKEFVDIVQP), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the protease inhibitor I35 (TIMP) family.
Protein Information
Name TIMP4
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Cellular Location Secreted.
Tissue Location Abundant in heart and present at low levels in many other tissues
Research Areas
Citations (0)
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Background

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. And this gene is mapped to chromosome 3p25. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.

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$ 280.00
Cat# ABO10561
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