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Anti-Beta Glucuronidase(Gusb) Antibody

     
  • WB - Anti-Beta Glucuronidase(Gusb) Antibody ABO11219
    Anti-beta glucuronidase(GUSB) antibody, ABO11219, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human GUSB, 40.9KD(162aa tag+ M1-P290)Lane 1: Recombinant Human GUSB Protein 10ngLane 2: Recombinant Human GUSB Protein 5ng
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  • WB - Anti-Beta Glucuronidase(Gusb) Antibody ABO11219
    Anti-beta glucuronidase(GUSB) antibody, ABO11219, Western blottingLane 1: HELA Cell LysateLane 2: SW620 Cell LysateLane 3: MCF-7 Cell Lysate
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P08236
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Beta-glucuronidase(GUSB) detection. Tested with WB in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 2990
Other Names Beta-glucuronidase, 3.2.1.31, Beta-G1, GUSB
Calculated MW 74732 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Lysosome.
Protein Name Beta-glucuronidase
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human beta glucuronidase(GUSB)(50-70aa DFSDNRRRGFEEQWYRRPLWE).
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name GUSB
Function Plays an important role in the degradation of dermatan and keratan sulfates.
Cellular Location Lysosome.
Research Areas
Citations (0)
citation

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Background

GUSB(Beta-Glucuronidase) is an enzyme that in humans is encoded by the GUSB gene. The GUSB gene encodes beta-glucuronidase, a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans. It is a tetrameric glycoprotein composed of identical subunits. The GUSB gene is mutated in mucopolysaccharidosis type VII. Miller et al.(1990) reported that the GUSB gene is 21 kb long and contains 12 exons. The GUSB gene is mapped on 7q11.21. Beta-glucuronic acid acts naturally to cleave glucuronides from conjugated bilirubin to produce unconjugated bilirubin, which is then absorbed into the bloodstream.Kreamer et al.(2001) postulated that the beta-glucuronidase inhibitor L-aspartic acid can thus block enterohepatic circulation of bilirubin. Tomatsu et al.(2002) stated that more than 45 different mutations in the GUSB gene had been identified in human patients with MPS VII, approximately 90% of which were point mutations.

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$ 240.00
Cat# ABO11219
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