Anti-PON2 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q15165 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Clonality | Polyclonal |
Format | Lyophilized |
Description | Rabbit IgG polyclonal antibody for Serum paraoxonase/arylesterase 2(PON2) detection. Tested with WB in Human;Mouse;Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene ID | 5445 |
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Other Names | Serum paraoxonase/arylesterase 2, PON 2, 3.1.1.2, 3.1.1.81, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2 |
Calculated MW | 39397 MW KDa |
Application Details | Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat |
Subcellular Localization | Membrane ; Peripheral membrane protein . |
Tissue Specificity | Widely expressed with highest expression in liver, lung, placenta, testis and heart. . |
Protein Name | Serum paraoxonase/arylesterase 2 |
Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human PON2(189-203aa FLKYLETYLNLHWAN), identical to the related mouse sequence, and different from the related rat sequence by one amino acid. |
Purification | Immunogen affinity purified. |
Cross Reactivity | No cross reactivity with other proteins |
Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
Sequence Similarities | Belongs to the paraoxonase family. |
Name | PON2 |
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Function | Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. |
Cellular Location | Membrane; Peripheral membrane protein |
Tissue Location | Widely expressed with highest expression in liver, lung, placenta, testis and heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PON2 is an enzyme that in humans is encoded by the PON2 gene. This gene is mapped to 7q21.3. This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones and important bacterial quorum-sensing mediators suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes.Â
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