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HSD17B4/MPF-2 Antibody

Rabbit Polyclonal Antibody

     
  • WB - HSD17B4/MPF-2 Antibody ABV10462-30
    Western blot analysis of HSD17B4/MPF-2 using mouse 3T3 cell lysate.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P51659
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 79686 Da
Additional Information
Gene ID 3295
Positive Control Mouse 3T3 cell lysate
Application & Usage The antibody can be used in Western Blot analysis (1-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.
Other Names Peroxisomal multifunctional enzyme type 2
Target/Specificity HSD17B4/MPF-2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti- HSD17B4/MPF-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsHSD17B4/MPF-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSD17B4 (HGNC:5213)
Synonyms EDH17B4, SDR8C1
Function Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3- hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates.
Cellular Location Peroxisome.
Tissue Location Present in many tissues with highest concentrations in liver, heart, prostate and testis
Research Areas
Citations (0)
citation

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Background

HSD17B4 (17-beta-hydroxysteroid dehydrogenase 4) is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. HSD17B4 catalyze the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.

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Discontinued
Cat# ABV10462-30
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