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Cox-4 Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P13073
Other Accession EAW95436
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 19577 Da
Additional Information
Gene ID 1327
Application & Usage Western blotting (0.5-4 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually.
Other Names COX 4 , COX4B , COX 4I2 , COX 4I1 , COX4I2 , COXIV 2 , COXIV , dJ857M17.2 , MGC72016
Target/Specificity Cox-4
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCox-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COX4I1 (HGNC:2265)
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Cellular Location Mitochondrion inner membrane; Single-pass membrane protein
Tissue Location Ubiquitous.
Research Areas
Citations (0)
citation

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Background

Cytochrome c oxidase (COX) is a 13-subunit complex spanning the inner mitochondrial membrane and responsible for the terminal reduction of dioxygen to water in the electron transport chain. The three core catalytic units COX-1, -2, -3 are trans-membrane proteins encoded by the mitochondrial genome, whereas the remaining 10 subunits are nuclear encoded and expressed in a tissue-specific manner. The expression of nuclear and mitochondrial subunits of the mitochondrial respiratory chain is tho µght to be highly coordinated. Cox-4 is believed to regulate COX activity according to the extramitochondrial ATP/ADP ratio.

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Discontinued
Cat# ABV10482-30
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