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IFN gamma Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P01580 |
| Other Accession | NP_032363 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17907 Da |
| Gene ID | 15978 |
|---|---|
| Application & Usage | Western blot analysis (0.5-4 µg/ml). Recombinant human IFN-gamma can be used as a positive control. However, the optimal conditions should be determined individually. |
| Other Names | Interferon gamma, IFNg, IFN-gamma, IFN gamma |
| Target/Specificity | IFNg |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-murine IFN-gamma polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, and 0.02% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | IFN gamma Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ifng |
|---|---|
| Function | Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:8456301, PubMed:11585387). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (PubMed:20535209, PubMed:25078851). |
| Cellular Location | Secreted {ECO:0000250|UniProtKB:P01579}. |
| Tissue Location | Released primarily from activated T lymphocytes. |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
IFN-gamma is a lymphoid factor that possesses potent anti-viral activity. It has also been shown that INF-gamma stimulates microphages and NK cells. Human IFN-gamma is a 16.9 kDa protein containing 144 amino acid residues.
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