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BMP-5 Antibody

Rabbit Polyclonal Antibody

     
  • WB - BMP-5 Antibody ABV11007-30
    Western blot analysis using recombinant human BMP-5.Lane 1: 50 ng;Lane2: 100 ng;Lane 3: 200 ng;Lane 4: 500 ng
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P22003
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 51737 Da
Additional Information
Gene ID 653
Positive Control Recombinant human BMP-5
Application & Usage The antibody can be used in Western Blot analysis (0.5-4 µg/ml). It detects monomer, dimer and trimer of BMP-5.
Other Names Bone morphogenetic protein 5, BMP-5
Target/Specificity BMP-5
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-human BMP-5 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsBMP-5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BMP5
Function Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509).
Cellular Location Secreted.
Tissue Location Expressed in the lung and liver.
Research Areas
Citations (0)
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Background

BMPs (bone morphogenetic proteins) belong to the TGF-βsuperfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. Active human BMP-5 is a 31 kDa homodimeric protein consisting of two 134 amino acid polypeptide chains.

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Discontinued
Cat# ABV11007-30
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