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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-CBR1 Antibody (2C9-B12-C4)   

Anti-CBR1 Antibody (2C9-B12-C4)

Mouse Monoclonal Antibody

     
  • WB - Anti-CBR1 Antibody (2C9-B12-C4) ABV12056-100
    Western blot detection of CBR1 in HeLa, A431 and MDAMB-468 cell lysates using CBR1 mouse mAb
    detail
  • ICC - Anti-CBR1 Antibody (2C9-B12-C4) ABV12056-100
    immunocytochemistry stain of HeLa using CBR1 mouse mAb
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession P16152
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names 2C9-B12-C4
Calculated MW 30375 Da
Additional Information
Gene ID 873
Application & Usage WB: HeLa, A431 and MDA-MB-468 cell lysates; IF: HeLa cells
Other Names Carbonyl reductase [NADPH] 1, 15-hydroxyprostaglandin dehydrogenase [NADP(+)], NADPH-dependent carbonyl reductase 1, Prostaglandin 9-ketoreductase, Prostaglandin-E(2) 9-reductase, Short chain dehydrogenase/reductase family 21C member 1
Target/Specificity CBR1
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS (pH 7.4) containing with 0.2% sodium azide, 50% glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAnti-CBR1 Antibody (2C9-B12-C4) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBR1 (HGNC:1548)
Synonyms CBR, CRN, SDR21C1
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:18449627, PubMed:15799708, PubMed:17912391, PubMed:7005231, PubMed:1921984, PubMed:17344335, PubMed:18826943). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione- conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:18826943, PubMed:17344335). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267).
Cellular Location Cytoplasm.
Tissue Location Expressed in kidney (at protein level).
Research Areas
Citations (0)
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Background

NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.

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Discontinued
Cat# ABV12056-100
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