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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > Cdc42-binding kinase alpha Antibody (N-Term)
Cdc42-binding kinase alpha Antibody (N-Term)
Peptide-affinity purified goat antibody
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- CITATIONS
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- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | Q5VT25 |
| Other Accession | NP_055641.3, NP_003598.2, 8476, 226751 (mouse), 114116 (rat) |
| Reactivity | Human |
| Predicted | Mouse, Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 197307 Da |
| Gene ID | 8476 |
|---|---|
| Other Names | Serine/threonine-protein kinase MRCK alpha, 2.7.11.1, CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, Myotonic dystrophy protein kinase-like alpha, CDC42BPA {ECO:0000312|EMBL:CAH71336.1}, KIAA0451 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Cdc42-binding kinase alpha Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC42BPA {ECO:0000312|EMBL:CAH71336.1} |
|---|---|
| Synonyms | KIAA0451 |
| Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O54874}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3UU96}. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Localizes in the lamellipodium in a FAM89B/LRAP25-dependent manner. {ECO:0000250|UniProtKB:O54874, ECO:0000250|UniProtKB:Q3UU96} |
| Tissue Location | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).
References
Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. Zhao Y, Loyer P, Li H, Valentine V, Kidd V, Kraft AS. J Biol Chem. 1997 Apr 11;272(15):10013-20. PMID: 9092543
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$ 341.00
Cat# AF2407a
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