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CLPB Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9H078 |
| Other Accession | NP_110440.1, 81570 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 78729 Da |
| Gene ID | 81570 |
|---|---|
| Other Names | Caseinolytic peptidase B protein homolog, Suppressor of potassium transport defect 3, CLPB, HSP78, SKD3 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLPB Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLPB (HGNC:30664) |
|---|---|
| Synonyms | SKD3 |
| Function | Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I- mediated signal transduction and production of IFNB1 and pro- inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842). |
| Cellular Location | Mitochondrion intermembrane space |
| Tissue Location | Widely expressed (at protein level) (PubMed:25597511). Expressed in fetal, as well as in adult tissues, with highest levels in adult brain, including thalamus, hippocampus, occipital cortex and parietal cortex. Low expression in granulocytes (PubMed:25597510). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Hsp104-dependent remodeling of prion complexes mediates protein-only inheritance. Satpute-Krishnan P, Langseth SX, Serio TR. PLoS Biol. 2007 Jan;5(2):e24. PMID: 17253904
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