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> home > Products > Primary Antibodies > Antibody Collections > Goat Antibodies > MARCH2 / MARCH-II Antibody (internal region)
MARCH2 / MARCH-II Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9P0N8 |
| Other Accession | NP_001005415.1, NP_001005416.1, NP_057580.3, 51257 |
| Predicted | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 26995 Da |
| Gene ID | 51257 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase MARCH2, 6.3.2.-, Membrane-associated RING finger protein 2, Membrane-associated RING-CH protein II, MARCH-II, RING finger protein 172, MARCH2, RNF172 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MARCH2 / MARCH-II Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MARCHF2 (HGNC:28038) |
|---|---|
| Synonyms | MARCH2, RNF172 |
| Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:14722266, PubMed:16428329). Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Ubiquitinates and therefore mediates the degradation of DLG1 (PubMed:17980554). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (PubMed:31142615). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6 (PubMed:15689499). |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi- pass membrane protein {ECO:0000250|UniProtKB:Q5I0I2}. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasm. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Broadly expressed.. |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking. Nakamura N, Fukuda H, Kato A, Hirose S. Mol Biol Cell. 2005 Apr;16(4):1696-710. Epub 2005 Feb 2. PMID: 15689499
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$ 216.00
Cat# AF2654a
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