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BDH2 / DHRS6 (aa 92 to 103) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| E |
|---|---|
| Primary Accession | Q9BUT1 |
| Other Accession | NP_064524.3, 56898, 69772 (mouse), 295458 (rat) |
| Predicted | Human, Mouse, Rat, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 26724 Da |
| Gene ID | 56898 |
|---|---|
| Other Names | 3-hydroxybutyrate dehydrogenase type 2, 1.1.1.-, 1.1.1.30, Dehydrogenase/reductase SDR family member 6, Oxidoreductase UCPA, R-beta-hydroxybutyrate dehydrogenase, Short chain dehydrogenase/reductase family 15C member 1, BDH2, DHRS6, SDR15C1 |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BDH2 / DHRS6 (aa 92 to 103) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BDH2 {ECO:0000303|PubMed:35150746, ECO:0000312|HGNC:HGNC:32389} |
|---|---|
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (PubMed:35150746) (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L- proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in liver (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U. J Biol Chem. 2006 Apr 14;281(15):10291-7. Epub 2005 Dec 27. PMID: 16380372
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