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TTLL4 Antibody (internal region)

Peptide-affinity purified goat antibody

     
  • WB - TTLL4 Antibody (internal region) AF3108a
    AF3108a (1 µg/ml) staining of MDCK lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q14679
Other Accession NP_055455.3, 9654, 67534 (mouse), 690512 (rat)
Reactivity Dog
Predicted Human, Mouse, Rat, Cow
Host Goat
Clonality Polyclonal
Concentration 0.5 mg/ml
Isotype IgG
Calculated MW 133378 Da
Additional Information
Gene ID 9654
Other Names Tubulin polyglutamylase TTLL4, 6.-.-.-, Tubulin--tyrosine ligase-like protein 4, TTLL4, KIAA0173
Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTTLL4 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTLL4 (HGNC:28976)
Synonyms KIAA0173
Function Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side- chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8} Note=Located in cilia. In some cells, also found in basal bodies {ECO:0000250|UniProtKB:Q80UG8}
Research Areas
Citations (0)
citation

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References

Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1. Trichet V, Ruault M, Roizès G, De Sario A, Gene 2000 Oct 257 (1): 109-17. PMID: 11054573

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$ 341.00
Cat# AF3108a
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