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CACNB2 (aa565-579) Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q08289 |
| Other Accession | NP_000715.2, NP_963890.2, NP_963884.2, NP_963891.1, NP_963887.2, NP_963865.2, NP_963864.1, NP_963866.2, NP_001161417.1, 783, 12296 (mouse), 116600 (rat) |
| Reactivity | Human, Mouse |
| Predicted | Rat, Dog, Cow |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 73581 Da |
| Gene ID | 783 |
|---|---|
| Other Names | Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNB2, CACNLB2, MYSB |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CACNB2 (aa565-579) Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACNB2 |
|---|---|
| Synonyms | CACNLB2, MYSB |
| Function | Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (By similarity). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (PubMed:17525370). |
| Cellular Location | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side |
| Tissue Location | Expressed in all tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_000715.2; NP_963890.2; NP_963884.2; NP_963891.1; NP_963887.2; NP_963865.2; NP_963864.1; NP_963866.2; NP_001161417.1).
References
Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes Burashnikov E, Pfeiffer R, Barajas-Martinez H, Delpón E, Hu D, Desai M, Borggrefe M, Häissaguerre M, Kanter R, Pollevick GD, Guerchicoff A, Laiño R, Marieb M, Nademanee K, Nam GB, Robles R, Schimpf R, Stapleton DD, Viskin S, Winters S, Wolpert C, Zimmern Heart Rhythm. 2010 Dec;7(12):1872-82. PMID: 20817017
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