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Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM139 ]

     
  • IHC -  Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide AH10530-20
    Formalin-fixed, paraffin-embedded human Pancreas stained with Insulin Monoclonal Antibody (SPM139).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, FC
Primary Accession P01308
Other Accession 3630, 272259
Reactivity Human, Pig, Cow
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM139
Calculated MW 6kDa
Additional Information
Gene ID 3630
Other Names Insulin, Insulin B chain, Insulin A chain, INS
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name INS
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Cellular Location Secreted.
Research Areas
Citations (0)
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Background

Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.

References

de la Tour, D., et al. 2001. Mol. Endoc. 15: 476-483. | Rajagopal, J., et al. 2003. Science 299: 363. | Morisset, J., et al. 2003. J. Histochem. Cytochem. 51: 1501-1513

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$ 219.00
$ 499.00
Cat# AH10530-20
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Availability: 3-5 days
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