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Neurofilament (H+L) (Neuronal Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone NF421 + NFL/736 ]

     
  • IHC -  Neurofilament (H+L) (Neuronal Marker) Antibody - With BSA and Azide AH12983-20
    Formalin-fixed, paraffin-embedded human Cerebellum stained with Neurofilament Monoclonal Antibody (NF421 + NFL/736).
    detail
  • IHC -  Neurofilament (H+L) (Neuronal Marker) Antibody - With BSA and Azide AH12983-20
    Formalin-fixed, paraffin-embedded human Cerebellum stained with Neurofilament Monoclonal Antibody (NF421 + NFL/736).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC, IF, FC
Primary Accession P12036
Other Accession 4744, 198760
Reactivity Human, Mouse, Rat, Pig, Chicken
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG's
Clone Names NF421 + NFL/736
Calculated MW 200kDa & 68kDa
Additional Information
Gene ID 4744
Other Names Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, KIAA0845, NFH
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Neurofilament (H+L) (Neuronal Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEFH
Synonyms KIAA0845, NFH
Function Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).
Cellular Location Cytoplasm, cytoskeleton. Cell projection, axon {ECO:0000250|UniProtKB:P19246}
Research Areas
Citations (0)
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Background

This MAb reacts with a 200kDa and 68kDa protein, identified as heavy and light sub-units of neurofilaments (NF-H & NF-L). Neurofilaments make up the main structural elements of axons and dendrites and are found in neurons, peripheral nerves, and sympathetic ganglion cells. Neurofilaments consist of three major subunits with molecular weights of 68kDa (NF-L), 160kDa (NF-M) and 200kDa (NF-H). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.

References

Ishii M et. al. Fukushima J Med Sci. 2004;50(2):65-74. | Angelides, K.J., et. al. 1989. J. Cell Biol. 108: 1495-1506

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$ 219.00
$ 499.00
Cat# AH12983-20
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