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Il5 antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P04401 |
| Other Accession | NM_010558, NP_034688 |
| Reactivity | Human, Mouse, Rat, Rabbit, Guinea Pig |
| Predicted | Human, Mouse, Rat, Guinea Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15kDa |
| Gene ID | 16191 |
|---|---|
| Alias Symbol | Il-5 |
| Other Names | Interleukin-5, IL-5, B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, T-cell replacing factor, TRF, Il5, Il-5 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Il5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Il5 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Il5 |
|---|---|
| Synonyms | Il-5 |
| Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10444455, PubMed:1873482). Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (PubMed:3128631). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity). |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Campbell H.D.,et al.Eur. J. Biochem. 174:345-352(1988).
Kinashi T.,et al.Nature 324:70-73(1986).
Mizuta T.R.,et al.Growth Factors 1:51-57(1988).
Takahashi T.,et al.Mol. Immunol. 27:911-920(1990).
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