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TPRKB antibody - middle region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y3C4 |
| Other Accession | NM_016058, NP_057142 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Horse, Yeast, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Pig, Chicken, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20kDa |
| Gene ID | 51002 |
|---|---|
| Alias Symbol | CGI-121 |
| Other Names | EKC/KEOPS complex subunit TPRKB, PRPK-binding protein, TP53RK-binding protein, TPRKB |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-TPRKB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TPRKB antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TPRKB (HGNC:24259) |
|---|---|
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828). |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Miyoshi A.,et al.Biochem. Biophys. Res. Commun. 303:399-405(2003).
Mao Y.M.,et al.Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
Lai C.-H.,et al.Genome Res. 10:703-713(2000).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Oppermann F.S.,et al.Mol. Cell. Proteomics 8:1751-1764(2009).
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