ELP4 Antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q96EB1 |
Other Accession | NP_061913 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Gene ID | 26610 |
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Alias Symbol | ELP4, C11orf19, PAXNEB, |
Other Names | Elongator complex protein 4, hELP4, PAX6 neighbor gene protein, ELP4, C11orf19, PAXNEB |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-ELP4 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ELP4 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ELP4 |
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Synonyms | C11orf19, PAXNEB |
Function | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
References
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Kleinjan D.A.,et al.Mamm. Genome 13:102-107(2002).
Hawkes N.A.,et al.J. Biol. Chem. 277:3047-3052(2002).
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