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DRG1 Antibody - middle region

Rabbit Polyclonal Antibody

     
  • WB - DRG1 Antibody - middle region AI16149

    Host: Rabbit
    Target Name: DRG1
    Sample Tissue: OVCAR-3 Whole Cell lysates
    Antibody Dilution: 1.0μg/ml
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Y295
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Additional Information
Gene ID 4733
Alias Symbol DRG1, NEDD3,
Other Names Developmentally-regulated GTP-binding protein 1, DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, DRG1, NEDD3
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-DRG1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsDRG1 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRG1 {ECO:0000303|PubMed:29915238, ECO:0000312|HGNC:HGNC:3029}
Function Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639).
Cellular Location Nucleus. Cytoplasm. Note=The DRG1-ZC3H15/DFRP1 complex associates with polysomes
Tissue Location High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes
Research Areas
Citations (0)
citation

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Background

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

References

Zhao X.-F.,et al.Biochim. Biophys. Acta 1448:109-114(1998).
Li B.,et al.Biochim. Biophys. Acta 1491:196-204(2000).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 389.00
Cat# AI16149
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