FKSG89 / MBOAT4 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
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Primary Accession | Q96T53 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 50kDa |
Dilution | IHC-P (5-10 µg/ml) |
Gene ID | 619373 |
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Other Names | Ghrelin O-acyltransferase, 2.3.1.-, Membrane-bound O-acyltransferase domain-containing protein 4, O-acyltransferase domain-containing protein 4, MBOAT4, GOAT, OACT4 |
Target/Specificity | Human MBOAT4. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except METTL10 (57%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | FKSG89 / MBOAT4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MBOAT4 (HGNC:32311) |
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Synonyms | GOAT, OACT4 |
Function | Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:24045953, PubMed:18443287, PubMed:25562443, PubMed:28134508). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl- CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C7A3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P0C7A3} |
Tissue Location | Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
References
Gutierrez J.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:6320-6325(2008).
Wang Y.-G.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 439:331-335(2006).
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