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ANAPC10 / APC10 Antibody (aa10-20)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UM13 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21kDa |
| Dilution | IHC-P (2.5 µg/ml) |
| Gene ID | 10393 |
|---|---|
| Other Names | Anaphase-promoting complex subunit 10, APC10, Cyclosome subunit 10, ANAPC10, APC10 |
| Target/Specificity | aa 10-20 of Human APC10 (Anaphase-promoting complex or cyclosome). |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | ANAPC10 / APC10 Antibody (aa10-20) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ANAPC10 |
|---|---|
| Synonyms | APC10 |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
References
Grossberger R.,et al.J. Biol. Chem. 274:14500-14507(1999).
Kurasawa Y.,et al.Oncogene 18:5131-5137(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Jin L.,et al.Cell 133:653-665(2008).
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