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CASP5 / Caspase 5 Antibody

Rabbit Polyclonal Antibody

     
  • ICC - CASP5 / Caspase 5 Antibody ALS11407
    Immunocytochemistry of caspase-5 in P815 cells with caspase-5 antibody at 2 ug/ml.
    detail
  • IF - CASP5 / Caspase 5 Antibody ALS11407
    Immunofluorescence of Caspase-5 in P815 cells with Caspase-5 antibody at 2 ug/ml.
    detail
  • WB - CASP5 / Caspase 5 Antibody ALS11407
    Western blot of caspase-5 in Ramos cells with caspase-5 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
    detail
  • IHC - CASP5 / Caspase 5 Antibody ALS11407
    Anti-CASP5 / Caspase 5 antibody IHC of human brain, cerebellum.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession P51878
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 838
Other Names Caspase-5, CASP-5, 3.4.22.58, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3
Target/Specificity 14 amino acid peptide from the center of human Caspase-5
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCASP5 / Caspase 5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP5 {ECO:0000303|PubMed:16893518, ECO:0000312|HGNC:HGNC:1506}
Function Thiol protease that acts as a mediator of programmed cell death (PubMed:29898893, PubMed:28314590). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin- D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
Tissue Location Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.
Research Areas
Citations (0)
citation

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Background

Mediator of programmed cell death (apoptosis).

References

Eckhart L.,et al.Biochem. Biophys. Res. Commun. 348:682-688(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Munday N.A.,et al.J. Biol. Chem. 270:15870-15876(1995).
Faucheu C.,et al.Eur. J. Biochem. 236:207-213(1996).

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$ 467.50
Cat# ALS11407
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