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DNASE2 / DNase II Antibody (aa347-360)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O00115 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40kDa |
| Dilution | IHC-P (5 µg/ml), WB (1:500-1:1000), |
| Gene ID | 1777 |
|---|---|
| Other Names | Deoxyribonuclease-2-alpha, 3.1.22.1, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2, DNASE2A, DNL2 |
| Target/Specificity | peptide corresponding to amino acids 347 to 360 of human DNase II precursor (2-4) |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | DNASE2 / DNase II Antibody (aa347-360) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNASE2 |
|---|---|
| Synonyms | DNASE2A, DNL2 |
| Function | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162). |
| Cellular Location | Lysosome. |
| Tissue Location | Expressed in monocytes/macrophages (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
References
Yasuda T.,et al.Ann. Hum. Genet. 62:299-305(1998).
Shiokawa D.,et al.Biochem. Biophys. Res. Commun. 247:864-869(1998).
Baker K.P.,et al.Gene 215:281-289(1998).
Krieser R.J.,et al.J. Biol. Chem. 273:30909-30914(1998).
Yasuda T.,et al.J. Biol. Chem. 273:2610-2616(1998).
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