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DUT / DUTPase Antibody (aa1-52)

Chicken Polyclonal Antibody

     
  • IHC - DUT / DUTPase Antibody (aa1-52) ALS11544
    Anti-DUT antibody IHC of human kidney.
    detail
  • IHC - DUT / DUTPase Antibody (aa1-52) ALS11544
    Anti-DUT antibody IHC of human pancreas.
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P33316
Reactivity Human
Host Chicken
Clonality Polyclonal
Calculated MW 27kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 1854
Other Names Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, dUTPase, 3.6.1.23, dUTP pyrophosphatase, DUT
Target/Specificity Amino acids 1-52 of human DUT
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsDUT / DUTPase Antibody (aa1-52) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUT
Function Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (PubMed:17880943, PubMed:8631816, PubMed:8805593). Inhibits peroxisome proliferator- activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (By similarity). Essential for embryonic development (By similarity).
Cellular Location [Isoform 2]: Nucleus
Tissue Location Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level)
Research Areas
Citations (0)
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Background

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

References

Ladner R.D.,et al.J. Biol. Chem. 271:7745-7751(1996).
Cohen D.,et al.Genomics 40:213-215(1997).
Pearlman R.E.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Ladner R.D.,et al.J. Biol. Chem. 272:19072-19080(1997).
Chano T.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS11544
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