RNF174 / MARCH4 Antibody (aa300-350)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | Q9P2E8 |
Reactivity | Human, Mouse, Rat, Zebrafish, Chicken, Opossum, Horse, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46kDa |
Dilution | IHC-P (5 µg/ml), WB (0.5-2 µg/ml), |
Gene ID | 57574 |
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Other Names | E3 ubiquitin-protein ligase MARCH4, 6.3.2.-, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, MARCH4, KIAA1399, RNF174 |
Target/Specificity | A portion of amino acids 300-350 of human RNF174 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | RNF174 / MARCH4 Antibody (aa300-350) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MARCHF4 (HGNC:29269) |
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Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein |
Tissue Location | Expressed in brain and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
References
Nagase T.,et al.DNA Res. 7:65-73(2000).
Bartee E.,et al.J. Virol. 78:1109-1120(2004).
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