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DNM1 / Dynamin Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q05193 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 97kDa |
| Dilution | ELISA (1 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml) |
| Gene ID | 1759 |
|---|---|
| Other Names | Dynamin-1, 3.6.5.5, DNM1, DNM |
| Target/Specificity | synthetic peptide corresponding to C-terminal residues of human DNM1(Dynamin-1) |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | DNM1 / Dynamin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNM1 (HGNC:2972) |
|---|---|
| Synonyms | DNM |
| Function | Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission and participates in many forms of endocytosis, such as clathrin-mediated endocytosis or synaptic vesicle endocytosis as well as rapid endocytosis (RE) (PubMed:8910402, PubMed:20428113, PubMed:15703209, PubMed:9362482, PubMed:29668686, PubMed:8101525). Associates to the membrane, through lipid binding, and self-assembles into rings and stacks of interconnected rings through oligomerization to form a helical polymer around the vesicle membrane leading to constriction of invaginated coated pits around their necks (PubMed:7877694, PubMed:9922133, PubMed:30069048). Self-assembly of the helical polymer induces membrane tubules narrowing until the polymer reaches a length sufficient to trigger GTP hydrolysis (PubMed:19084269). Depending on the curvature imposed on the tubules, membrane detachment from the helical polymer upon GTP hydrolysis can cause spontaneous hemifission followed by complete fission (PubMed:19084269). May play a role in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through its activation by dephosphorylation via the signaling downstream of EGFR (PubMed:29668686). Controls vesicle size at a step before fission, during formation of membrane pits, at hippocampal synapses (By similarity). Controls plastic adaptation of the synaptic vesicle recycling machinery to high levels of activity (By similarity). Mediates rapid endocytosis (RE), a Ca(2+)-dependent and clathrin- and K(+)-independent process in chromaffin cells (By similarity). Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP (By similarity). Through its interaction with DNAJC6, acts during the early steps of clathrin-coated vesicle (CCV) formation (PubMed:12791276). |
| Cellular Location | Cell membrane. Membrane, clathrin-coated pit. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P21575, ECO:0000250|UniProtKB:P39053} Presynapse {ECO:0000250|UniProtKB:P21575}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule {ECO:0000250|UniProtKB:Q08DF4} Note=Associated to the membrane in an helical polymer shape in a GTP bound state (PubMed:30069048). Transiently recruited to endocytic clathrin-coated pits (CCPs) at a late stage of clathrin-coated vesicle (CCV) formation (PubMed:15703209). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
References
van der Bliek A.M.,et al.J. Cell Biol. 122:553-563(1993).
Humphray S.J.,et al.Nature 429:369-374(2004).
Soulet F.,et al.Mol. Biol. Cell 16:2058-2067(2005).
Olsen J.V.,et al.Cell 127:635-648(2006).
Krendel M.,et al.FEBS Lett. 581:644-650(2007).
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