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CBX5 / HP1 Alpha Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P45973 |
| Reactivity | Human, Monkey, Pig, Sheep, Horse, Bovine |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 22kDa |
| Dilution | ELISA (1:128000), IHC-P (2.5 µg/ml), WB (1:128000) |
| Gene ID | 23468 |
|---|---|
| Other Names | Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A |
| Target/Specificity | Human CBX5 / HP1. Variants (NP_036249.1; NP_001120793.1; NP_001120794.1) encode the same protein. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | CBX5 / HP1 Alpha Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CBX5 |
|---|---|
| Synonyms | HP1A |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
| Cellular Location | Nucleus. Chromosome. Chromosome, centromere Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346) Component of centromeric and pericentromeric heterochromatin Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase (PubMed:19617346) Localizes to sites of DNA damage (PubMed:28977666) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
References
Saunders W.S.,et al.J. Cell Sci. 104:573-582(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Ye Q.,et al.J. Biol. Chem. 271:14653-14656(1996).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
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