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CLPP Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - CLPP Antibody (C-Terminus) ALS12445
    Anti-CLPP antibody IHC of human liver.
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  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q16740
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 30kDa
Dilution ELISA (1:64000), IHC-P (2.5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 8192
Other Names ATP-dependent Clp protease proteolytic subunit, mitochondrial, 3.4.21.92, Endopeptidase Clp, CLPP
Target/Specificity Human CLPP.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCLPP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLPP
Function Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782). Cleaves PINK1 in the mitochondrion (PubMed:22354088).
Cellular Location Mitochondrion matrix
Tissue Location Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney
Research Areas
Citations (0)
citation

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Background

Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.

References

Bross P.,et al.FEBS Lett. 377:249-252(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
de Sagarra M.R.,et al.J. Mol. Biol. 292:819-825(1999).
Kang S.G.,et al.J. Biol. Chem. 277:21095-21102(2002).

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Discontinued
Cat# ALS12445
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