CLPP Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q16740 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 30kDa |
Dilution | ELISA (1:64000), IHC-P (2.5 µg/ml), WB (1-3 µg/ml) |
Gene ID | 8192 |
---|---|
Other Names | ATP-dependent Clp protease proteolytic subunit, mitochondrial, 3.4.21.92, Endopeptidase Clp, CLPP |
Target/Specificity | Human CLPP. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | CLPP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLPP |
---|---|
Function | Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed:11923310, PubMed:15522782). Cleaves PINK1 in the mitochondrion (PubMed:22354088). |
Cellular Location | Mitochondrion matrix |
Tissue Location | Detected in liver (at protein level). Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
References
Bross P.,et al.FEBS Lett. 377:249-252(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Xu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009).
de Sagarra M.R.,et al.J. Mol. Biol. 292:819-825(1999).
Kang S.G.,et al.J. Biol. Chem. 277:21095-21102(2002).
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