DAGLA Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q9Y4D2 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 115kDa |
Dilution | ELISA (1:128000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml) |
Gene ID | 747 |
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Other Names | Sn1-specific diacylglycerol lipase alpha, DGL-alpha, 3.1.1.-, Neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR |
Target/Specificity | Human DAGLA. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | DAGLA Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DAGLA |
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Synonyms | C11orf11, KIAA0659, NSDDR {ECO:0000303|R |
Function | Serine hydrolase that hydrolyzes arachidonic acid-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2- arachidonoylglycerol (2-AG) (PubMed:14610053, PubMed:26668358, PubMed:23502535). Preferentially hydrolyzes sn-1 fatty acids from diacylglycerols (DAG) that contain arachidonic acid (AA) esterified at the sn-2 position to biosynthesize 2-AG (PubMed:14610053, PubMed:26668358, PubMed:23502535). Has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in regulating 2-AG signaling in the central nervous system (CNS). Regulates 2-AG involved in retrograde suppression at central synapses. Supports axonal growth during development and adult neurogenesis. Plays a role for eCB signaling in the physiological regulation of anxiety and depressive behaviors. Regulates also neuroinflammatory responses in the brain, in particular, LPS-induced microglial activation (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic density membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q6WQJ1}; Multi-pass membrane protein. Note=Cycles between the cell surface and an intracellular endosomal compartment. Internalized by early endosomes via a clathrin-independent pathway before transport back to the postsynaptic membrane surface in a PKC-dependent manner |
Tissue Location | Highly expressed in brain and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
References
Horiguchi S.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bisogno T.,et al.J. Cell Biol. 163:463-468(2003).
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