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HIPK1 Antibody (clone 1D6)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q86Z02 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 1D6 |
| Calculated MW | 131kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 204851 |
|---|---|
| Other Names | Homeodomain-interacting protein kinase 1, 2.7.11.1, Nuclear body-associated kinase 2, HIPK1, KIAA0630, MYAK, NBAK2 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | HIPK1 Antibody (clone 1D6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HIPK1 |
|---|---|
| Synonyms | KIAA0630, MYAK, NBAK2 |
| Function | Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Phosphorylates PAGE4 at 'Thr-51' which is critical for the ability of PAGE4 to potentiate the transcriptional activator activity of JUN (PubMed:24559171). |
| Cellular Location | Nucleus. Cytoplasm. Nucleus speckle. Note=Predominantly nuclear Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation. |
| Tissue Location | Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines Isoform 2 is highly expressed in testis. Expressed in both androgen- dependent and androgen-independent prostate cancer cells (PubMed:28289210). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti- oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
References
Miyata Y.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
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