TRPM7 Antibody (aa1817-1863, clone S74-25)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, ICC, IP |
---|---|
Primary Accession | Q96QT4 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | S74-25 |
Calculated MW | 213kDa |
Dilution | ICC (0.1-1 µg/ml), IHC-P (5 µg/ml), IP (1-10 µg/ml), WB (1-10 µg/ml) , |
Gene ID | 54822 |
---|---|
Other Names | Transient receptor potential cation channel subfamily M member 7, 2.7.11.1, Channel-kinase 1, Long transient receptor potential channel 7, LTrpC-7, LTrpC7, TRPM7, CHAK1, LTRPC7 |
Target/Specificity | Detects ~220 kD protein. No cross reactivity with TrpM6. |
Reconstitution & Storage | Store at -20°C. |
Precautions | TRPM7 Antibody (aa1817-1863, clone S74-25) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRPM7 |
---|---|
Synonyms | CHAK1, LTRPC7 |
Function | Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741). Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). |
Cellular Location | Membrane; Multi-pass membrane protein |
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Background
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
References
Nadler M.J.S.,et al.Nature 411:590-595(2001).
Nadler M.J.S.,et al.Nature 412:660-660(2001).
Ryazanova L.V.,et al.J. Biol. Chem. 279:3708-3716(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmitz C.,et al.Cell 114:191-200(2003).
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