SNX4 Antibody (aa438-450)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | O95219 |
Reactivity | Human, Mouse, Rat, Rabbit, Monkey, Horse, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 52kDa |
Dilution | IHC-P (3.75-7.5 µg/ml) |
Gene ID | 8723 |
---|---|
Other Names | Sorting nexin-4, SNX4 |
Target/Specificity | Human SNX4. A phox (PX) domain protein. In mouse, there is also a hypothetical protein called similar to SNX4 (XP_123014.1), which is virtually identical to SNX4. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | SNX4 Antibody (aa438-450) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SNX4 {ECO:0000303|PubMed:9819414, ECO:0000312|HGNC:HGNC:11175} |
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Function | Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622). |
Cellular Location | Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also detected on a juxtanuclear endocytic recycling compartment (ERC). |
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Background
May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.
References
Haft C.R.,et al.Mol. Cell. Biol. 18:7278-7287(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Traer C.J.,et al.Nat. Cell Biol. 9:1370-1380(2007).
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