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SLC12A1 / NKCC2 Antibody (aa43-57)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q13621 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 121kDa |
| Dilution | IHC-P (3.75-7.5 µg/ml) |
| Gene ID | 6557 |
|---|---|
| Other Names | Solute carrier family 12 member 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, SLC12A1, NKCC2 |
| Target/Specificity | Human SLC12A1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | SLC12A1 / NKCC2 Antibody (aa43-57) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC12A1 |
|---|---|
| Synonyms | NKCC2 {ECO:0000303|PubMed:8640224} |
| Function | Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). Electrically silent transporter system (By similarity). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Kidney; localizes to the thick ascending limbs (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
References
Simon D.B.,et al.Nat. Genet. 13:183-188(1996).
Di Fulvio M.,et al.Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).
Cruz-Rangel S.,et al.Am. J. Physiol. 301:C601-C608(2011).
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