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KRT19 / CK19 / Cytokeratin 19 Antibody (clone RCK108)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC, Flo, IHC-Fr |
|---|---|
| Primary Accession | P08727 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | RCK108 |
| Calculated MW | 44kDa |
| Dilution | Flo (1:100-1:200), IHC-Fr (1:100-1:200), IHC-P (10 µg/ml), WB (1:100-1:1000) , |
| Gene ID | 3880 |
|---|---|
| Other Names | Keratin, type I cytoskeletal 19, Cytokeratin-19, CK-19, Keratin-19, K19, KRT19 |
| Target/Specificity | Reacts exclusively with cytokeratin 19 which is present in glandular-type epithelia and most carcinomas. Does not react with hepatocytes and hepatocellular carcinoma. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | KRT19 / CK19 / Cytokeratin 19 Antibody (clone RCK108) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KRT19 |
|---|---|
| Function | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Tissue Location | Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. |
| Volume | Array |
Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
References
Stasiak P.C.,et al.Nucleic Acids Res. 15:10058-10058(1987).
Bader B.L.,et al.Eur. J. Cell Biol. 47:300-319(1988).
Eckert R.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:1114-1118(1988).
Stasiak P.C.,et al.J. Invest. Dermatol. 92:707-716(1989).
Whittock N.V.,et al.Biochem. Biophys. Res. Commun. 267:462-465(2000).
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