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CD79B Antibody (Intracellular, clone AT107-2)
Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, IP, Flo |
|---|---|
| Primary Accession | P40259 |
| Reactivity | Human, Rat, Pig, Dog |
| Host | Rat |
| Clonality | Monoclonal |
| Clone Names | AT107-2 |
| Calculated MW | 26kDa |
| Dilution | Flo (1:50-1:100), IHC-P (2 µg/ml), |
| Gene ID | 974 |
|---|---|
| Other Names | B-cell antigen receptor complex-associated protein beta chain, B-cell-specific glycoprotein B29, Ig-beta, Immunoglobulin-associated B29 protein, CD79b, CD79B, B29, IGB |
| Target/Specificity | Recognizes an intracellular region of human and mouse CD79b, a cell surface antigen expressed by B lymphocytes. The CD79b molecule (also known as Ig beta and B29) associates with CD79a to form a heterodimer that is covalently linked to surface immuno ... |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | CD79B Antibody (Intracellular, clone AT107-2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD79B |
|---|---|
| Synonyms | B29, IGB |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts. |
| Tissue Location | B-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.
References
Mueller B.S.,et al.Eur. J. Immunol. 22:1621-1625(1992).
Wood W.J. Jr.,et al.Genomics 16:187-192(1993).
Hashimoto S.,et al.J. Immunol. 150:491-498(1993).
Hashimoto S.,et al.Immunogenetics 40:145-149(1994).
Hashimoto S.,et al.Mol. Immunol. 32:651-659(1995).
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