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TRIM39 / RNF23 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - TRIM39 / RNF23 Antibody (C-Terminus) ALS14941
    Anti-TRIM39 / RNF23 antibody IHC of human uterus.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9HCM9
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Dog
Host Goat
Clonality Polyclonal
Calculated MW 60kDa
Dilution ELISA (1:32000), IHC-P (3.75 µg/ml),
Additional Information
Gene ID 56658
Other Names E3 ubiquitin-protein ligase TRIM39, 6.3.2.-, RING finger protein 23, Testis-abundant finger protein, Tripartite motif-containing protein 39, TRIM39, RNF23, TFP
Target/Specificity Human TRIM39 / RNF23. This antibody is expected to recognise both reported isoforms (NP_067076.2 and NP_742013.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsTRIM39 / RNF23 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM39
Synonyms RNF23, TFP
Function [Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex- mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251).
Cellular Location [Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus.
Tissue Location Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis
Research Areas
Citations (0)
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Background

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

References

Orimo A.,et al.Biochem. Biophys. Res. Commun. 276:45-51(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shiina T.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Shiina T.,et al.Genetics 173:1555-1570(2006).

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Discontinued
Cat# ALS14941
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