TRIM39 / RNF23 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, E |
---|---|
Primary Accession | Q9HCM9 |
Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 60kDa |
Dilution | ELISA (1:32000), IHC-P (3.75 µg/ml), |
Gene ID | 56658 |
---|---|
Other Names | E3 ubiquitin-protein ligase TRIM39, 6.3.2.-, RING finger protein 23, Testis-abundant finger protein, Tripartite motif-containing protein 39, TRIM39, RNF23, TFP |
Target/Specificity | Human TRIM39 / RNF23. This antibody is expected to recognise both reported isoforms (NP_067076.2 and NP_742013.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | TRIM39 / RNF23 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRIM39 |
---|---|
Synonyms | RNF23, TFP |
Function | [Isoform 1]: E3 ubiquitin-protein ligase (PubMed:22529100). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (PubMed:19100260, PubMed:22529100). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (PubMed:23213251). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex- mediated CDKN1A/p21 ubiquitination and degradation (PubMed:23213251). |
Cellular Location | [Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. |
Tissue Location | Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.
References
Orimo A.,et al.Biochem. Biophys. Res. Commun. 276:45-51(2000).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Shiina T.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Shiina T.,et al.Genetics 173:1555-1570(2006).
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