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SENP1 Antibody (aa1-50)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9P0U3 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73kDa |
| Dilution | ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500-1:1000) |
| Gene ID | 29843 |
|---|---|
| Other Names | Sentrin-specific protease 1, 3.4.22.68, Sentrin/SUMO-specific protease SENP1, SENP1 |
| Target/Specificity | SENP1 Antibody detects endogenous levels of total SENP1 protein. |
| Reconstitution & Storage | Store at -20°C for up to one year. |
| Precautions | SENP1 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SENP1 |
|---|---|
| Function | Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Deconjugates SUMO1 from METTL3 (PubMed:29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844). |
| Cellular Location | Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus |
| Tissue Location | Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.
References
Gong L.,et al.J. Biol. Chem. 275:3355-3359(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Bailey D.,et al.J. Biol. Chem. 279:692-703(2004).
Cheng J.,et al.Mol. Cell. Biol. 24:6021-6028(2004).
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