SLC6A3 / Dopamine Transporter Antibody (EL2 Region)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-Fr |
---|---|
Primary Accession | Q01959 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 68kDa |
Dilution | IHC-Fr (1:1000), IHC-P (1:100), WB (1:1000) |
Gene ID | 6531 |
---|---|
Other Names | Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, SLC6A3, DAT1 |
Target/Specificity | Specific for the ~88k DAT protein in Western blots |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Precautions | SLC6A3 / Dopamine Transporter Antibody (EL2 Region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC6A3 |
---|---|
Synonyms | DAT1 |
Function | Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1406597, PubMed:8302271, PubMed:10375632, PubMed:11093780, PubMed:15505207, PubMed:19478460). Also mediates sodium- and chloride- dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity) {ECO:0000250|UniProtKB:P23977, ECO:0000250|UniProtKB:Q61327} |
Tissue Location | Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554) |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
References
Vandenbergh D.J.,et al.Brain Res. Mol. Brain Res. 15:161-166(1992).
Giros B.,et al.Mol. Pharmacol. 42:383-390(1992).
Pristupa Z.B.,et al.Mol. Pharmacol. 45:125-135(1994).
Kawarai T.,et al.Gene 195:11-18(1997).
Vandenbergh D.J.,et al.Mol. Psychiatry 5:283-292(2000).
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