GATA4 Antibody (aa330-380)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | P43694 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
Gene ID | 2626 |
---|---|
Other Names | Transcription factor GATA-4, GATA-binding factor 4, GATA4 |
Target/Specificity | Human GATA4 |
Reconstitution & Storage | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
Precautions | GATA4 Antibody (aa330-380) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GATA4 |
---|---|
Function | Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724, PubMed:35182466). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it down-regulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1- phosphate degrading enzyme, sphingosine-1-phosphate lyase (PubMed:15734735). |
Cellular Location | Nucleus |
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Background
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development.
References
Huang W.Y.,et al.Gene 155:219-223(1995).
Palaszewski I.,et al.Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 439:331-335(2006).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
Sunagawa Y.,et al.J. Biol. Chem. 285:9556-9568(2010).
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