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SLC22A3 / OCT3 Antibody (aa275-324)

Rabbit Polyclonal Antibody

     
  • WB - SLC22A3 / OCT3 Antibody (aa275-324) ALS15804
    Western blot of extracts from HUVEC/COLO/HT-29 cells, using SLC22A3 Antibody.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O75751
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 61kDa
Dilution ELISA (1:10000), IHC-P (20 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 6581
Other Names Solute carrier family 22 member 3, Extraneuronal monoamine transporter, EMT, Organic cation transporter 3, SLC22A3, EMTH, OCT3
Target/Specificity SLC22A3 Antibody detects endogenous levels of total SLC22A3 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsSLC22A3 / OCT3 Antibody (aa275-324) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC22A3 (HGNC:10967)
Function Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10196521, PubMed:10966924, PubMed:12538837, PubMed:17460754, PubMed:20858707). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10966924). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:12538837). Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:10196521, PubMed:16581093, PubMed:20858707). Transports dopaminergic neuromodulators cyclo(his- pro) and salsolinol with low efficiency (PubMed:17460754). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (PubMed:10966924). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:10966924). May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:O88446}. Endomembrane system {ECO:0000250|UniProtKB:O88446}. Nucleus membrane {ECO:0000250|UniProtKB:O88446}. Nucleus outer membrane {ECO:0000250|UniProtKB:O88446}. Note=Localized to the apical/brush border membrane of enterocytes (PubMed:16263091). Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714). Localized to the basolateral membrane of intermediate cells in bronchi (PubMed:15817714). Localized to the entire plasma membrane of basal cells in bronchi (PubMed:15817714)
Tissue Location Expressed in liver (PubMed:10196521, PubMed:9933568). Expressed in intestine (PubMed:16263091, PubMed:20858707). Expressed in kidney in proximal tubular cells (PubMed:10966924). Expressed in placenta (PubMed:9933568, PubMed:10966924). Expressed throughout the brain, including cerebral cortex, cerebrellum, substancia nigra, medulla oblongata, hippocampus, caudate nucleus, nucleus accumbens and pons with low levels of expression detected in nearly all brain regions (PubMed:10196521, PubMed:20858707). In testis, mostly localized to peritubular myoid cells and Leydig cells, and weakly expressed in developing germ cells (PubMed:35307651). Expressed in tracheal and bronchial epithelium of the respiratory tract, where it localizes to the apical membrane of ciliated cells, the entire membrane of basal cells and the basolateral membrane of intermediate cells (PubMed:15817714). Expressed in skeletal muscle, adrenal gland, heart, prostate, aorta, salivary gland, adrenal gland, uterus, lymph node, lung, trachea and spinal cord (PubMed:10196521, PubMed:9933568, PubMed:20858707). Expressed in fetal lung and liver (PubMed:9933568).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

References

Gruendemann D.,et al.Nat. Neurosci. 1:349-351(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Verhaagh S.,et al.Genomics 55:209-218(1999).

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$ 467.50
Cat# ALS15804
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