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RASSF10 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - RASSF10 Antibody (N-Terminus) ALS15851
    Anti-RASSF10 antibody IHC staining of human testis.
    detail
  • WB - RASSF10 Antibody (N-Terminus) ALS15851
    Western blot analysis of RASSF10 in human lung tissue lysate with RASSF10 antibody at 1 ug/ml
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession A6NK89
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution IHC-P (5 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 644943
Other Names Ras association domain-containing protein 10, RASSF10
Target/Specificity Human RASSF10. RASSF10 antibody will not cross-react with other RAS association domain-containing family members.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsRASSF10 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RASSF10
Function Plays an important role in regulating embryonic neurogenesis.
Cellular Location Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm
Tissue Location Expressed in brain. Tends to be down-regulated in astrocytic gliomas due to promoter methylation. Methylation occurs early in gliomagenesis and the extent of methylation parallels with higher glioma grades, so that methylation is observed in close to 70% WHO grade IV primary glioblastomas, but not in grade I astrocytomas
Research Areas
Citations (0)
citation

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References

Taylor T.D.,et al.Nature 440:497-500(2006).
Sherwood V.,et al.Mol. Biol. Cell 19:1772-1782(2008).
Hill V.K.,et al.Oncogene 30:978-989(2011).

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$ 467.50
Cat# ALS15851
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