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COX4I2 Antibody (aa31-80)

Rabbit Polyclonal Antibody

     
  • IHC - COX4I2 Antibody (aa31-80) ALS15898
    Anti-COX4I2 antibody IHC staining of human kidney.
    detail
  • IF - COX4I2 Antibody (aa31-80) ALS15898
    Immunofluorescence of COS7 cells, using COX42 Antibody.
    detail
  • WB - COX4I2 Antibody (aa31-80) ALS15898
    Western blot of extracts from K562 cells, treated with insulin 0.01U/ml 15', using COX42 Antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q96KJ9
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 20kDa
Dilution ELISA (1:10000), IF (1:100-1:500), IHC-P (20 µg/ml), WB (1:500-1:1000) ,
Additional Information
Gene ID 84701
Other Names Cytochrome c oxidase subunit 4 isoform 2, mitochondrial, Cytochrome c oxidase subunit IV isoform 2, COX IV-2, COX4I2, COX4L2
Target/Specificity COX42 Antibody detects endogenous levels of total COX42 protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsCOX4I2 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COX4I2 (HGNC:16232)
Function Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00423}; Single-pass membrane protein {ECO:0000250|UniProtKB:P00423}
Tissue Location Highly expressed in lung.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

References

Huettemann M.,et al.Gene 267:111-123(2001).
Deloukas P.,et al.Nature 414:865-871(2001).
Shteyer E.,et al.Am. J. Hum. Genet. 84:412-417(2009).

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Discontinued
Cat# ALS15898
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