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ALDOB Antibody (aa111-160)

Rabbit Polyclonal Antibody

     
  • IHC - ALDOB Antibody (aa111-160) ALS15929
    Anti-ALDOB antibody IHC staining of human kidney.
    detail
  • IHC - ALDOB Antibody (aa111-160) ALS15929
    Anti-ALDOB antibody IHC staining of human liver.
    detail
  • WB - ALDOB Antibody (aa111-160) ALS15929
    Western blot of extracts from MCF-7/HUVEC cells, using ALDOB Antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P05062
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 229
Other Names Fructose-bisphosphate aldolase B, 4.1.2.13, Liver-type aldolase, ALDOB, ALDB
Target/Specificity ALDOB Antibody detects endogenous levels of total ALDOB protein.
Reconstitution & Storage Store at -20°C for up to one year.
PrecautionsALDOB Antibody (aa111-160) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDOB {ECO:0000303|PubMed:15880727, ECO:0000312|HGNC:HGNC:417}
Function Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D- glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde (PubMed:10970798, PubMed:12205126, PubMed:20848650). Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check (PubMed:35122041).
Cellular Location Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Volume 50 µl
Research Areas
Citations (0)
citation

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References

Paolella G.,et al.Nucleic Acids Res. 12:7401-7410(1984).
Sakakibara M.,et al.Nucleic Acids Res. 13:5055-5069(1985).
Rottmann W.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 81:2738-2742(1984).
Mukai T.,et al.J. Biochem. 102:1043-1051(1987).
Tolan D.R.,et al.Mol. Biol. Med. 3:245-264(1986).

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Discontinued
Cat# ALS15929
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