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CTNS / Cystinosin Antibody (clone 5G6)

Mouse Monoclonal Antibody

     
  • WB - CTNS / Cystinosin Antibody (clone 5G6) ALS16254
    CTNS monoclonal antibody (M09), clone 5G6. Western Blot analysis of CTNS expression in human liver.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O60931
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Clone Names 5G6
Calculated MW 42kDa
Dilution IHC-P (1:100)
Additional Information
Gene ID 1497
Other Names Cystinosin, CTNS
Target/Specificity Human CTNS / Cystinosin
Reconstitution & Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsCTNS / Cystinosin Antibody (clone 5G6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CTNS {ECO:0000303|PubMed:9537412, ECO:0000312|HGNC:HGNC:2518}
Function Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:15128704, PubMed:36113465). Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis (PubMed:22649030). In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes (PubMed:36113465). Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity (By similarity).
Cellular Location [Isoform 1]: Lysosome membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein. Note=AP-3 complex is required for localization to the lysosome.
Tissue Location Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes (PubMed:22649030). Expressed at lower levels in placenta and heart Weakly expressed in lung, liver and brain (adult and fetal) (PubMed:22649030).
Research Areas
Citations (0)
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Background

Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.

References

Town M.,et al.Nat. Genet. 18:319-324(1998).
Touchman J.W.,et al.Genome Res. 10:165-173(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS16254
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