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ARFIP1 Antibody (aa271-320)

Rabbit Polyclonal Antibody

     
  • IHC - ARFIP1 Antibody (aa271-320) ALS16643
    Anti-ARFIP1 antibody IHC staining of human colon.
    detail
  • IF - ARFIP1 Antibody (aa271-320) ALS16643
    Immunofluorescence of A549 cells, using ARFIP1 Antibody.
    detail
  • WB - ARFIP1 Antibody (aa271-320) ALS16643
    Western blot of extracts from Jurkat cells, using ARFIP1 Antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P53367
Other Accession 27236
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 41738 Da
Dilution ELISA (1:40000), IF (1:100 - 1:500), IHC-P (20 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 27236
Other Names ARFIP1, Arfaptin-1, Arfaptin 1, HSU52521
Target/Specificity ARFIP1 Antibody detects endogenous levels of total ARFIP1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsARFIP1 Antibody (aa271-320) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ARFIP1 {ECO:0000303|PubMed:22981988, ECO:0000312|HGNC:HGNC:21496}
Function Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanistically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988).
Cellular Location Golgi apparatus. Golgi apparatus, trans-Golgi network membrane
Tissue Location Ubiquitously expressed (PubMed:9038142). Higher levels in liver, pancreas, placenta, skeletal muscle and heart (PubMed:9038142).
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Putative target protein of ADP-ribosylation factor.

References

Kanoh H.,et al.J. Biol. Chem. 272:5421-5429(1997).
Premont R.T.,et al.Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS16643
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