DNAJB11 Antibody (aa31-80)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q9UBS4 |
Other Accession | 51726 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 40514 Da |
Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 51726 |
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Other Names | DNAJB11, ABBP-2, ABBP2, APOBEC1-binding protein 2, DJ9, DnaJ protein 9, DnaJ protein homolog 9, EDJ, ERj3, ERj3p, HDJ9, ER-associated dnaJ protein 3, Human DnaJ protein 9, HDj-9, HEDJ, UNQ537, Dj-9, ER-associated DNAJ, ERdj3, PRO1080 |
Target/Specificity | DNAJB11 Antibody detects endogenous levels of total DNAJB11 protein. |
Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
Precautions | DNAJB11 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DNAJB11 |
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Synonyms | EDJ, ERJ3, HDJ9 |
Function | As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). |
Cellular Location | Endoplasmic reticulum lumen Note=Associated with the ER membrane in a C-terminally epitope-tagged construct |
Tissue Location | Widely expressed. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.
References
Ohtsuka K.,et al.Cell Stress Chaperones 5:98-112(2000).
Yu M.,et al.J. Biol. Chem. 275:24984-24992(2000).
Bies C.,et al.Biol. Chem. 385:389-395(2004).
Honore B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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