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ASPA Antibody (aa39-300)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | P45381 |
| Other Accession | 443 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 35735 Da |
| Dilution | ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:500 - 1:3000), |
| Gene ID | 443 |
|---|---|
| Other Names | ASPA, ACY2, Aminoacylase-2, ACY-2, Aspartoacylase, Aminoacylase 2, ASP |
| Target/Specificity | Human ASPA |
| Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | ASPA Antibody (aa39-300) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ASPA (HGNC:756) |
|---|---|
| Function | Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q9R1T5}. Nucleus {ECO:0000250|UniProtKB:Q9R1T5} |
| Tissue Location | Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
References
Kaul R.,et al.Nat. Genet. 5:118-123(1993).
Moore R.A.,et al.Arch. Biochem. Biophys. 413:1-8(2003).
Herga S.,et al.FEBS Lett. 580:5899-5904(2006).
Le Coq J.,et al.Biochemistry 47:3484-3492(2008).
Bitto E.,et al.Proc. Natl. Acad. Sci. U.S.A. 104:456-461(2007).
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