SNTA1 / Syntrophin Alpha 1 Antibody (aa191-505)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, ICC |
---|---|
Primary Accession | Q13424 |
Other Accession | 6640 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 53895 Da |
Dilution | ICC (1:100 - 1:1000), IHC-P (7.5 µg/ml), WB (1:1000 - 1:10000), |
Gene ID | 6640 |
---|---|
Other Names | SNTA1, Acidic alpha 1 syntrophin, DJ1187J4.5, Alpha-1-syntrophin, SNT1, Syntrophin Alpha 1, Syntrophin, alpha 1, Syntrophin-1, LQT12, TACIP1 |
Target/Specificity | Human SNTA1 / Syntrophin Alpha 1 |
Reconstitution & Storage | 0.1 M Tris-glycine, pH 7.0, 20% glycerol, 0.01% Thimerosal. Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
Precautions | SNTA1 / Syntrophin Alpha 1 Antibody (aa191-505) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SNTA1 |
---|---|
Synonyms | SNT1 |
Function | Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). |
Cellular Location | Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions |
Tissue Location | High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta |
Volume | 50 µl |
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Background
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate (By similarity).
References
Ahn A.H.,et al.J. Biol. Chem. 271:2724-2730(1996).
Castello A.,et al.FEBS Lett. 383:124-128(1996).
Hasegawa M.,et al.J. Biol. Chem. 274:12626-12631(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).
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